People often use "No rest for the wicked" in a rather comedic sense. Like, it's Monday morning and I have to go back to work. "No rest for the wicked". Turns out, the phrase originated from the Bible, and the original meaning wasn't comedic. It's referring to the wicked spending eternity in hell.
“But those who still reject me are like the restless sea, which is never still but continually churns up mud and dirt. There is no peace for the wicked,” says my God.